In the shaky video, she says she's drunk and doesn't know where she is going. She also says she thinks she's driving on a flat tire.
"Where am I right now, people?" the woman asks, over the sound of music playing in her car. "I have to go home."
Police in Lakeland, Florida, have identified the driver as 23-year-old Whitney Marie Beall. She was arrested and faces a charge of driving under the influence.
Her attorney reportedly released a statement saying that Beall would not be giving any interviews any time soon.
"She is a young professional with a bright future. When her court date is set, I will be entering a plea on her behalf of not guilty," attorney Lee Cohen said in a statement reported by CNN affiliate WFLA.
"I'll be investigating the case and that starts now. I am waiting to see all the evidence, and I will take a look at it," Cohen said.
Police began getting calls about Beall on Saturday from people who saw the live stream and were concerned.
"She was out of it. And it's obvious from watching that livestreaming video how bad she was," Lakeland police Sgt. Gary Gross told CNN affiliate Bay News 9.
Officers found Beall, who, in fact, was driving on a flat tire, police said in a statement. Just as a traffic stop was started, her car hit the curb.
According to police, Beall's speech was slow and officers smelled alcohol. She also allegedly appeared to be disoriented.
Beall was arrested after she refused a breathalyzer and failed field sobriety tests.
"The streaming Periscope video highlights the dangers of driving while intoxicated through the eyes of a drunk and irresponsible young adult," said police.
"The Lakeland Police Department is extremely thankful that this did not result in an accident and no one was injured as a result of her poor decision."